Ami’s friend, Yoshie, was murdered and desecrated by the Kimura Gang. She was saved and, like Ami in the previous film, received modifications from the same mechanics. Remembering her past, Yoshie decides to avenge herself and Ami.
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On a remote former submarine refueling facility called Aquatica, a team of scientists are searching for a cure for Alzheimer’s disease. Dr. Susan McAlester genetically engineers three Mako sharks, intending to increase their brain capacity so that they can harvest the tissue as a cure for Alzheimer’s. Unfortunately, the increased brain capacity also makes the sharks smarter, faster, and more dangerous. Aquatica’s financial backers are skeptical and nervous about the tests, and send a corporate executive to visit the facility.